Antibody dynamics in BRSV-infected Danish dairy herds as determined by isotype-specific immunoglobulins
Identifieur interne : 001163 ( Main/Exploration ); précédent : 001162; suivant : 001164Antibody dynamics in BRSV-infected Danish dairy herds as determined by isotype-specific immunoglobulins
Auteurs : Se Uttenthal [Danemark] ; Lars Erik Larsen [Danemark] ; Jens Stege Philipsen [Danemark] ; Kirsten Tj Rneh J [Danemark] ; Birgitte Viuff [Danemark] ; Knud Herby Nielsen [Danemark] ; Thomas Krogh Nielsen [Danemark]Source :
- Veterinary Microbiology [ 0378-1135 ] ; 2000.
Descripteurs français
- Wicri :
- topic : Bovin.
English descriptors
- KwdEn :
- Teeft :
- Antibody, Blood samples, Bovine, Bovine coronavirus, Brsv, Brsv antibodies, Brsv antigen, Brsv infection, Calf, Clinical signs, Clinical symptoms, Control antigen, Control calf, Corona, Corona virus, Coronavirus, Dairy herds, Danish dairy herds, December, Elisa, Enzootic pneumonia, Igg1, Igg1 igg2, Igg1 titres, Igg2, Igg2 antibodies, Igg2 isotypes, Infection, Isotypes, Kimman, Larsen, Lavage, Lung lavage, Maternal antibodies, Maternal immunity, Microbiology, Nasal swabs, Natural infection, Neutralising antibodies, Observation period, Passive immunity, Rectal temperature, Respiratory disease, Serum samples, Swab, Syncytial, Syncytial virus, Test samples, Titre, Uttenthal, Veterinary microbiology.
Abstract
Abstract: Using specific ELISAs, antibody levels of four different isotypes to bovine respiratory syncytial virus (BRSV) were determined in calves, following experimental BRSV infection. Most calves experienced an increase in the specific IgM and IgG1 titres about 6–10 days after infection with BRSV. The IgM titre was transient showing positive titres for only 5–10 days, while specific IgG1 was present for a longer time. IgA was detected concomitantly with IgM but at a lower level. Production of IgG2 anti-BRSV antibodies was detected from 3 weeks after infection. In two closed herds, repeated blood samplings were performed on young stock to analyse maternal immunity. The passively transferred antibodies were mainly of the IgG1 isotype and the half-life of IgG1 to BRSV was estimated to be 26.6 days. One of the herds had an outbreak of enzootic pneumonia, diagnosed to be caused by BRSV. Furthermore, another herd with acute BRSV was followed by weekly blood samples in six calves; in both herds IgM and IgG1 was detected shortly after the appearance of clinical signs. Serum samples from 50 Danish dairy herds (453 samples) were tested for immunoglobulins of the isotypes IgG1, IgG2 and IgM. The presence of antibodies to BRSV was widespread and more than 54% of the samples had BRSV antibodies of both the IgG1 and IgG2 isotypes indicating a high herd prevalence to BRSV. Test samples from two herds out of 50 were free from all isotypes to BRSV.
Url:
DOI: 10.1016/S0378-1135(00)00261-3
Affiliations:
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RSV</term><term>Cattle</term><term>Immunoglobulin isotypes</term><term>Maternal immunity</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Antibody</term><term>Blood samples</term><term>Bovine</term><term>Bovine coronavirus</term><term>Brsv</term><term>Brsv antibodies</term><term>Brsv antigen</term><term>Brsv infection</term><term>Calf</term><term>Clinical signs</term><term>Clinical symptoms</term><term>Control antigen</term><term>Control calf</term><term>Corona</term><term>Corona virus</term><term>Coronavirus</term><term>Dairy herds</term><term>Danish dairy herds</term><term>December</term><term>Elisa</term><term>Enzootic pneumonia</term><term>Igg1</term><term>Igg1 igg2</term><term>Igg1 titres</term><term>Igg2</term><term>Igg2 antibodies</term><term>Igg2 isotypes</term><term>Infection</term><term>Isotypes</term><term>Kimman</term><term>Larsen</term><term>Lavage</term><term>Lung lavage</term><term>Maternal antibodies</term><term>Maternal immunity</term><term>Microbiology</term><term>Nasal swabs</term><term>Natural infection</term><term>Neutralising antibodies</term><term>Observation period</term><term>Passive immunity</term><term>Rectal temperature</term><term>Respiratory disease</term><term>Serum samples</term><term>Swab</term><term>Syncytial</term><term>Syncytial virus</term><term>Test samples</term><term>Titre</term><term>Uttenthal</term><term>Veterinary microbiology</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Bovin</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Using specific ELISAs, antibody levels of four different isotypes to bovine respiratory syncytial virus (BRSV) were determined in calves, following experimental BRSV infection. Most calves experienced an increase in the specific IgM and IgG1 titres about 6–10 days after infection with BRSV. The IgM titre was transient showing positive titres for only 5–10 days, while specific IgG1 was present for a longer time. IgA was detected concomitantly with IgM but at a lower level. Production of IgG2 anti-BRSV antibodies was detected from 3 weeks after infection. In two closed herds, repeated blood samplings were performed on young stock to analyse maternal immunity. The passively transferred antibodies were mainly of the IgG1 isotype and the half-life of IgG1 to BRSV was estimated to be 26.6 days. One of the herds had an outbreak of enzootic pneumonia, diagnosed to be caused by BRSV. Furthermore, another herd with acute BRSV was followed by weekly blood samples in six calves; in both herds IgM and IgG1 was detected shortly after the appearance of clinical signs. Serum samples from 50 Danish dairy herds (453 samples) were tested for immunoglobulins of the isotypes IgG1, IgG2 and IgM. The presence of antibodies to BRSV was widespread and more than 54% of the samples had BRSV antibodies of both the IgG1 and IgG2 isotypes indicating a high herd prevalence to BRSV. Test samples from two herds out of 50 were free from all isotypes to BRSV.</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><country name="Danemark"><noRegion><name sortKey="Uttenthal, Se" sort="Uttenthal, Se" uniqKey="Uttenthal " first=" Se" last="Uttenthal"> Se Uttenthal</name></noRegion><name sortKey="Larsen, Lars Erik" sort="Larsen, Lars Erik" uniqKey="Larsen L" first="Lars Erik" last="Larsen">Lars Erik Larsen</name><name sortKey="Nielsen, Knud Herby" sort="Nielsen, Knud Herby" uniqKey="Nielsen K" first="Knud Herby" last="Nielsen">Knud Herby Nielsen</name><name sortKey="Nielsen, Thomas Krogh" sort="Nielsen, Thomas Krogh" uniqKey="Nielsen T" first="Thomas Krogh" last="Nielsen">Thomas Krogh Nielsen</name><name sortKey="Philipsen, Jens Stege" sort="Philipsen, Jens Stege" uniqKey="Philipsen J" first="Jens Stege" last="Philipsen">Jens Stege Philipsen</name><name sortKey="Tj Rneh J, Kirsten" sort="Tj Rneh J, Kirsten" uniqKey="Tj Rneh J K" first="Kirsten" last="Tj Rneh J">Kirsten Tj Rneh J</name><name sortKey="Uttenthal, Se" sort="Uttenthal, Se" uniqKey="Uttenthal " first=" Se" last="Uttenthal"> Se Uttenthal</name><name sortKey="Viuff, Birgitte" sort="Viuff, Birgitte" uniqKey="Viuff B" first="Birgitte" last="Viuff">Birgitte Viuff</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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